Ukungalali rhoqo kunye nokuvuka kwangethuba, isiyezi esingachazwanga kunye nokudinwa, i-acne engapheliyo, kunye neengxaki zokugaya ukutya ezitshintshatshintshayo… ezi mpawu zingajongwa lula zinokunxulunyaniswa nokudumba okungapheliyo. Ukudumba okungapheliyo kwaziwa ngokuba "ngumbulali othuleyo," ohlala emzimbeni ixesha elide, utshabalalisa izicubu kunye namalungu omzimba buthule. Okubi nangakumbi kukuba, kunokusebenza "njengesithintelo" sokubuyela komhlaza kwakhona.
01. Ukudumba Okungapheliyo
"Isixhobo" sokuvuselela umhlaza
Uphononongo olusandul’ ukwenzeka olupapashwe kwiProceedings of the National Academy of Sciences ngamaqela ophando avela kwiChinese Academy of Sciences kunye neMassachusetts Institute of Technology luqinisekisa ukuba ukudumba okungapheliyo kunokuvusa iiseli zomhlaza ezileleyo kwiindawo ezikude, nto leyo ebangela ukuba umhlaza usasazeke kwaye uphinde ubuye.
Abaphandi, ngokusebenzisa uvavanyo olwenziwe kwiimpuku, bafumanise ukuba ezinye iiseli zomhlaza webele ezikhula ziye emiphungeni zingena “kwimeko yokungalali,” ezingazahluliyo okanye ezingakhiyo iithumba. Nangona kunjalo, xa ukudumba kubangelwa yimiphunga, ezi seli zomhlaza “ezileleyo” ziyavuswa ngempumelelo, ziphinde zikwazi ukwahlulahlula, ukwanda, kwaye zenze iithumba ezikhula ngokukhawuleza.
02. Ukudumba okungapheliyo
Nguye unobangela wezifo zonke.
Kwiimeko eziqhelekileyo, ukudumba yindlela yokuzikhusela yomzimba ekwenzakaleni nasekosulelekeni. Nangona kunjalo, xa izinto ezifana noxinzelelo olungapheliyo kunye nokungalali kakuhle zithintela olu khuselo ukuba luphele ngexesha elifanelekileyo, oko kukhokelela ekudumbeni okungapheliyo okubangelwa yinkqubo yomzimba yokuzikhusela esebenza kakhulu. Olu vuselelo oluqhubekayo lokudumba ludala umjikelo ombi womonakalo kunye nokulungiswa kwezicwili zomzimba, ekugqibeleni kukhokelela ekungasebenzi kakuhle kwamalungu omzimba kunye nokubonelela ngomhlaba ovundileyo wokukhula nokusasazeka kweeseli zomhlaza.
Ngaphezu koko, ukudumba okungapheliyo kunxulunyaniswa kakhulu nophuhliso lwezifo ezahlukeneyo: kwinkqubo yentliziyo, ukudumba okungapheliyo kunokonakalisa i-endothelium yemithambo yegazi, kukhawulezise i-atherosclerosis, kwaye kwandise umngcipheko we-hypertension, isifo sentliziyo, kunye ne-myocardial infarction; kwinkqubo ye-metabolic, izinto ezivuthayo zinokuphazamisana novakalelo lwe-insulin, zibangele isifo seswekile sohlobo lwesibini; kwaye nezifo ezifana nesifo sika-Alzheimer kunye ne-rheumatoid arthritis ziqinisekisiwe ukuba zidibene nokudumba okungapheliyo.
03. Iingenelo ezimbini kwinto enye, ezipheleleyo nezipheleleyo
Ukwakha ukhuselo olupheleleyo lokulwa nokuvuvukala komzimba wonke
Ke ngoko, ukuphucula ukudumba okungapheliyo yindlela ephambili yokuzikhusela ekugcineni impilo. Ukongeza ekuthinteleni okusisiseko ngendlela yokuphila enempilo, unyango lokukhanya okubomvu, olunendlela yalo eyahlukileyo yokusebenza kunye neempawu ezikhuselekileyo nezingenasithintelo, luye lwasetyenziswa kakhulu ekunyangeni izifo ezahlukeneyo ezivuthayo nezibuhlungu, ezifana nokwenzakala kwezicubu ezithambileyo, isifo samathambo, kunye namanxeba esikhumba, kwaye luye lwafumana iziphumo zonyango ezibalulekileyo.
Uphononongo olupapashwe kwi *Chinese Journal of Pain Medicine* luqinisekisile ukuba ukukhanya okubomvu kunokunciphisa kakhulu amanqanaba e-inflammatory factor IL-1β kunye ne-pain-inducing mediator PGE2 kwindawo yokwenzakala, nto leyo ebonisa ngokucacileyo iziphumo zayo ezimbini zokulwa nokuvuvukala kunye ne-analgesic kunye nokukwazi kwayo ukunciphisa ngempumelelo iimpawu zokuvuvukala ezifana nokubomvu, ukudumba, intlungu, kunye nokutsha.
Izifundo zeklinikhi kwiinkalo ezahlukeneyo zibonise ukuba ukukhanya okubomvu, emva kokuba kufakwe kakuhle yi-mitochondria, kunokuphucula ukwenziwa kwe-ATP, kunike amandla okulungisa. Ukungena kwayo ngamandla kukwakhuthaza ukusasazeka kwemithambo yegazi kwiithishu ezinzulu, kwandisa ukunikezelwa kweoksijini kwaye kuncede ekususeni iimveliso zemetabolism ezivuthayo, ngaloo ndlela kukhawulezise ukusombulula iimpendulo zokudumba. Ngaphezu koko, ukukhanya okubomvu kunokukhuthaza ii-fibroblast, okukhokelela ekwandeni kwe-collagen fiber kwaye kukhuthaze ukuphiliswa kwamanxeba kunye nezilonda.
I-capsule ye-Merican phototherapy, esekelwe kunyango lokukhanya okubomvu, idlula kwimida yendabuko ngeenzuzo zayo eziphambili "zokugubungela ngokupheleleyo kunye nonyango olupheleleyo," okuvelisa iziphumo ze-photobiological kuwo wonke umzimba. Esi siphumo singena nzulu kwi-mitochondria, siphucula ukusebenza kakuhle kokuzilungisa kwaye siphucula ukunikezelwa kweoksijini. Oku, ngakolunye uhlangothi, kuphucula kancinci imiba yokudumba evela kwiinkalo ezahlukeneyo, kubandakanya ukuvuselelwa kwamandla, ukususwa kwenkunkuma, kunye nokulawulwa kwemiqondiso. Ngaphezu koko, idibanisa imithombo emininzi yokukhanya ukunceda imisebenzi yomzimba ibuyele kwimeko yokulinganisela kunye namandla ayo.
Iingenelo ezimbini: Ifikelela kumbane olinganayo kuwo wonke umzimba kwaye ifikelele ngamandla apheleleyo, ivumela ukukhanya okubomvu ukuba kusebenze ngaxeshanye kuwo onke amalungu omzimba, nto leyo ebangela ukuphuculwa kwenkqubo yomzimba.
• Amandla aphezulu: Ixhotyiswe ngamandla aphezulu, inika ukusebenza okuqinileyo nokuzinzileyo, ijolise ngqo kwiimfuno eziphambili ezifana nokulwa nokudumba kunye nokulungiswa.
• Indlela ebanzi: Ijongana nonobangela wophuculo olupheleleyo, ifezekisa ukuphuculwa kwempilo ngeendlela ezininzi ngexesha elinye.
Okokugqibela, nangona ukudumba okungapheliyo kungabonakali kwaye kufikelela kwiindawo ezininzi, akulawuleki. Ngokusekelwe kwindlela yokuphila esempilweni, kunye namaqhinga okungenelela kwesayensi, singaphumelela ngakumbi kule mpi yexesha elide yokulwa nokudumba. Ngamana wonke umntu angakhululeka kwiingxaki zokudumba aze amkele ubomi obusempilweni!