Imiba ye-Thyroid ixhaphake kuluntu lwanamhlanje, ichaphazela zonke izini kunye neminyaka ukuya ngamanqanaba ahlukeneyo.Ukuxilongwa mhlawumbi kuphoswa rhoqo kunayo nayiphi na enye imeko kwaye unyango oluqhelekileyo / imimiselo yemiba ye-thyroid ngamashumi eminyaka emva kokuqonda kwesayensi kwimeko.
Umbuzo esiza kuwuphendula kweli nqaku - Ngaba unyango olulula ludlala indima ekuthinteleni kunye nonyango lweengxaki ze-thyroid / i-metabolism ephantsi?
Xa sijonga kuncwadi lwenzululwazi siyayibona loo ntounyango olululaImpembelelo yedlala lengqula ifundwe amaxesha amaninzi, ebantwini (umz. Höfling DB et al., 2013), iimpuku (umz. Azevedo LH et al., 2005), imivundla (umz. Weber JB et al., 2014), phakathi kwabanye.Ukuqonda ukuba kutheniunyango olululaingaba, okanye ingabi nomdla kwaba baphandi, okokuqala kufuneka siqonde iziseko.
Intshayelelo
I-Hypothyroidism (i-thyroid ephantsi, i-thyroid engasebenzi kakuhle) kufuneka ithathelwe ingqalelo ngakumbi njengento ewela kuwo wonke umntu, kunokuba imeko emnyama okanye emhlophe ehlaselwa ngabantu abadala kuphela.Ngokucacileyo nabani na kuluntu lwanamhlanje unamanqanaba afanelekileyo e-hormone yegilo (Klaus Kapelari et al., 2007. Hershman JM et al., 1993. JM Corcoran et al., 1977.).Ukongeza kwisiphithiphithi, kukho oonobangela kunye neempawu ezihambelanayo kunye neminye imiba yemetabolism efana nesifo seswekile, isifo sentliziyo, i-IBS, i-cholesterol ephezulu, uxinzelelo kunye nokulahleka kweenwele (Betsy, 2013. Kim EY, 2015. Islam S, 2008, Dorchy H, Ngo-1985.).
Ukuba 'nemetabolism ecothayo' yeyona nto ifana ne-hypothyroidism, yiyo loo nto ihambelana nezinye iingxaki emzimbeni.Ifunyaniswa kuphela njengekliniki ye-hypothyroidism xa ifikelele kwindawo ephantsi.
Ngamafutshane, i-hypothyroidism yimeko yokuvelisa amandla aphantsi kuwo wonke umzimba ngenxa ye-hormone ye-thyroid ephantsi.Izizathu eziqhelekileyo zintsonkothile, kubandakanywa ukutya okwahlukeneyo kunye neendlela zokuphila ezifana;uxinzelelo, ufuzo, ukwaluphala, amafutha e-polyunsaturated, ukutya okunekhabhohayidrethi ephantsi, ukutya okunekhalori ephantsi, ukungalali ngokwaneleyo, utywala, kunye nokuzilolonga ngokugqithisileyo.Ezinye izinto ezinjengotyando lokususa idlala lengqula, ukuthatha i-fluoride, iindlela ezahlukeneyo zonyango, njalo njalo zibangela i-hypothyroidism.
Unyango olukhanyayo olunokuba luncedo kubantu abaphantsi kwe-thyroid?
Ukukhanya okubomvu kunye ne-infrared (600-1000nm)inokuba luncedo kwimetabolism emzimbeni kumanqanaba ahlukeneyo ahlukeneyo.
1. Olunye uphando lugqibe kwelokuba ukusebenzisa ukukhanya okubomvu ngokufanelekileyo kunokuphucula ukuveliswa kweehomoni.(Höfling et al., 2010,2012,2013. Azevedo LH et al., 2005. Вера Александровна, 2010. Gopkalova, I. 2010.) Njengayo nayiphi na izicubu emzimbeni, i-thyroid gland ifuna amandla okwenza yonke imisebenzi yayo. .Njengoko ihomoni yegilo idlala indima ephambili ekuvuseleleni imveliso yamandla, unokubona indlela ukungabikho kwayo kwiiseli zedlala kunciphisa ukuveliswa kwehomoni yegilo - umjikelo okhohlakeleyo weklasikhi.I-thyroid ephantsi -> amandla aphantsi -> i-thyroid ephantsi -> njl.
2. Unyango olukhanyayoxa isetyenziswe ngokufanelekileyo entanyeni inokuthi iphule lo mjikelezo onobuqhetseba, kwithiyori ngokuphucula ukufumaneka kwamandla wendawo, ngaloo ndlela ukwandisa ukuveliswa kwehomoni ye-thyroid nge-gland kwakhona.Ngempilo ye-thyroid gland ebuyiselweyo, ininzi yemiphumo emihle ezantsi yenzeke, njengoko umzimba wonke ekugqibeleni ufumana amandla afunekayo (Mendis-Handagama SM, 2005. Rajender S, 2011).I-hormone ye-Steroid (i-testosterone, i-progesterone, njl. njl.) i-synthesis iphinda ithathe kwakhona - isimo sengqondo, i-libido kunye namandla aphuculwayo, ubushushu bomzimba buyanda kwaye ngokusisiseko zonke iimpawu ze-metabolism ephantsi ziguqulwa (Amy Warner et al., 2013) - kwanokubonakala komzimba kunye umtsalane ngokwesondo kwandisa.
3. Ngokuhambisana neenzuzo zenkqubo enokubakho ukusuka ekuvezweni kwe-thyroid, ukusebenzisa ukukhanya naphi na emzimbeni kunokunika iziphumo zenkqubo, ngegazi (Ihsan FR, 2005. Rodrigo SM et al., 2009. Leal Junior EC et al., 2010).Nangona iiseli ezibomvu zegazi azinayo i-mitochondria;iiplatelets zegazi, iiseli ezimhlophe zegazi kunye nezinye iindidi zeeseli ezikhoyo egazini zinemitochondria.Oku kukodwa kuphononongwa ukuze kubonwe indlela kwaye kutheni kunokunciphisa ukuvuvukala kunye namanqanaba e-cortisol - i-hormone yoxinzelelo ethintela i-T4 -> ukusebenza kwe-T3 (Albertini et al., 2007).
4. Ukuba umntu ebenokufaka isibane esibomvu kwiindawo ezithile zomzimba (ezifana nobuchopho, ulusu, amasende, amanxeba, njl.njl.), abanye abaphandi baqikelele ukuba mhlawumbi oko kunokunika ukomelela okukhulu kwendawo.Oku kuboniswa ngcono ngezifundo zonyango olukhanyayo kwiziphazamiso zesikhumba, amanxeba kunye nosulelo, apho kwizifundo ezahlukeneyo ixesha lokuphilisa linokuncitshiswa.ukukhanya okubomvu okanye infrared(J. Ty Hopkins et al., 2004. Avci et al., 2013, Mao HS, 2012. Percival SL, 2015. da Silva JP, 2010. Gupta A, 2014. Güngörmüş M, 2009).Isiphumo sendawo yokukhanya sinokubonakala sinokwahluka kodwa sihambelana nomsebenzi wendalo wehomoni yegilo.
Ithiyori engundoqo kunye neyamkelwe ngokubanzi yempembelelo ethe ngqo yonyango olulula ibandakanya ukuveliswa kwamandla eselula.Iziphumo kucingelwa ukuba zenziwe ngokuyintloko nge-photodissociating nitric oxide (NO) ukusuka kwi-enzayimu ye-mitochondrial (i-cytochrome c oxidase, njl.).Unokucinga ngo-HAYI njengokhuphisana onobungozi kwi-oksijini, efana ne-carbon monoxide.HAYI ngokusisiseko ivala imveliso yamandla kwiiseli, isenza imeko-bume emosha kakhulu ngamandla, ethi emazantsi omlambo inyuse i-cortisol/uxinzelelo.Isibane esibomvuIthiyori yokuthintela le nitric oxide ityhefu, kunye nesiphumo soxinzelelo, ngokuyisusa kwi-mitochondria.Ngale ndlela ukukhanya okubomvu kunokucingelwa 'njengochaso olukhuselayo loxinzelelo', kunokuba kwandiswe ngokukhawuleza imveliso yamandla.Kukuvumela nje i-mitochondria yeeseli zakho ukuba isebenze ngokufanelekileyo ngokunciphisa iziphumo ezidambisayo zoxinzelelo, ngendlela ihomoni yegilo kuphela engenzi ngayo.
Ke ngelixa i-hormone ye-thyroid iphucula ukubala kwe-mitochondria kunye nokusebenza kakuhle, i-hypothesis ejikeleze unyango olulula kukuba inokuphucula kwaye iqinisekise iziphumo ze-thyroid ngokuthintela iimolekyuli ezinxulumene noxinzelelo.Kusenokubakho ezinye iindlela ezininzi ezingathanga ngqo apho zombini i-thyroid kunye nokukhanya okubomvu kunciphisa uxinzelelo, kodwa asizukungena kuzo apha.
Iimpawu zomgangatho ophantsi we-metabolic / hypothyroidism
Isantya sentliziyo esisezantsi (ngaphantsi kwama-75 bpm)
Ubushushu bomzimba obuphantsi, ngaphantsi kwama-98°F/36.7°C
Soloko uziva ugodola (umz. izandla neenyawo)
Ulusu olomileyo naphi na emzimbeni
Iingcamango eziguquguqukayo / ezinomsindo
Ukuziva uxinzelelo / ukuxhalaba
Inkungu yengqondo, intloko ebuhlungu
Iinwele/iinzipho ezikhula kancinci
Imiba yamathumbu (ukuqhinwa, ukuqhinwa, i-IBS, i-SIBO, ukuqunjelwa, isitshisa, njl.njl.)
Ukuchama rhoqo
Phantsi/akukho libido (kunye/okanye ukuqina okubuthathaka / ukuthambisa kakubi kwelungu lobufazi)
Ukuba buthathaka kwegwele/candida
Umjikelezo wokuya esikhathini ongahambelaniyo, unzima, ubuhlungu
Ubudlolo
Ukuncipha ngokukhawuleza kweenwele / ukubola kweenwele.Amashiya amancinci
Ubuthongo obubi
Isebenza njani inkqubo ye-thyroid?
I-hormone ye-thyroid iqala ukuveliswa kwi-thyroid gland (ebekwe entanyeni) njengoko ininzi i-T4, kwaye ihamba ngegazi ukuya esibindini nakwezinye izicubu, apho iguqulwa ibe yifom esebenzayo ngakumbi - i-T3.Olu hlobo olusebenzayo lwehomoni yegilo emva koko luhamba lusiya kuyo yonke iseli yomzimba, lusebenza ngaphakathi kweeseli ukuphucula imveliso yamandla eselula.Ngoko idlala lengqula -> isibindi -> zonke iiseli.
Yintoni edla ngokungahambi kakuhle kule nkqubo yemveliso?Kwikhonkco lomsebenzi wehomoni ye-thyroid, nayiphi na inqaku inokubangela ingxaki:
1. Idlala lengqula ngokwalo alinakukwazi ukuvelisa iincindi zamadlala ngokwaneleyo.Oku kunokuba phantsi kokunqongophala kwe-iodine ekutyeni, ukugqithiswa kwe-polyunsaturated fatty acids (PUFA) okanye i-goitrogens ekutyeni, utyando lwangaphambili lwe-thyroid, into ebizwa ngokuba yi-autoimmune imeko kaHashimoto, njl.
2. Isibindi asikwazanga 'ukuvuselela' i-hormone (T4 -> T3), ngenxa yokungabikho kwe-glucose / glycogen, ukugqithisa kwe-cortisol, umonakalo wesibindi ngenxa yokukhuluphala, utywala, iziyobisi kunye nokusuleleka, ukugqithiswa kwentsimbi, njl.
3. Iiseli kusenokwenzeka ukuba azifunxa iihomoni ezikhoyo.Ukufunxwa kweeseli kwehomoni yegilo esebenzayo kudla ngokuhla kwizinto zokutya.Amafutha e-Polyunsaturated ukusuka ekutyeni (okanye kumafutha agciniweyo akhululwa ngexesha lokulahleka kwesisindo) ngokwenene avimbela ihomoni ye-thyroid ekungeneni kwiiseli.I-glucose, okanye iiswekile ngokubanzi (i-fructose, i-sucrose, i-lactose, i-glycogen, njl.), zibalulekile ekufunxeni nasekusebenziseni i-hormone ye-thyroid esebenzayo ngeeseli.
I-hormone ye-thyroid kwiseli
Ukucinga ukuba akukho mqobo kukho ukuveliswa kwehomoni ye-thyroid, kwaye inokufikelela kwiiseli, yenza ngokuthe ngqo kwaye ngokungathanga ngqo kwinkqubo yokuphefumula kwiiseli - ezikhokelela kwi-oxidation epheleleyo ye-glucose (kwi-carbon dioxide).Ngaphandle kwehomoni yegilo eyaneleyo ukuba 'idibanise' iiproteni ze-mitochondrial, inkqubo yokuphefumla ayinakugqiba kwaye idla ngokukhokelela kwi-lactic acid kunemveliso yokugqibela ye-carbon dioxide.
Ihomoni ye-Thyroid isebenza kuzo zombini i-mitochondria kunye ne-nucleus yeeseli, ezibangela iziphumo zexesha elifutshane kunye nexesha elide eziphucula i-oxidative metabolism.Kwi-nucleus, i-T3 icingelwa ukuba inefuthe ekubonakalisweni kofuzo oluthile, olukhokelela kwi-mitochondriogenesis, oku kuthetha ukuba ngaphezulu / i-mitochondria entsha.Kwi-mitochondria esele ikhona, isebenzisa amandla angqalileyo okuphucula isiphumo nge-cytochrome oxidase, kunye nokungadibanisi ukuphefumla kwimveliso ye-ATP.
Oku kuthetha ukuba i-glucose inokutyhalwa phantsi kwendlela yokuphefumla ngaphandle kokuvelisa i-ATP.Ngelixa oku kunokubonakala kuyinkcitho, konyusa umthamo wekharbon diokside enenzuzo, kwaye iyeke iswekile ukuba igcinwe njenge lactic acid.Oku kunokubonwa ngokusondeleyo kubantu abanesifo seswekile, abathi rhoqo bafumane amanqanaba aphezulu e-lactic acid ekhokelela kwisimo esibizwa ngokuba yi-lactic acidosis.Abantu abaninzi be-hypothyroid bade bavelise i-lactic acid ebalulekileyo ekuphumleni.Ihomoni ye-thyroid idlala indima ngqo ekunciphiseni le meko iyingozi.
I-hormone ye-thyroid inomnye umsebenzi emzimbeni, ukudibanisa ne-vitamin A kunye ne-cholesterol ukwenza i-pregnenolone - isandulela kuzo zonke iihomoni ze-steroid.Oku kuthetha ukuba amanqanaba aphantsi e-thyroid abangela amanqanaba aphantsi e-progesterone, i-testosterone, njl.Ihomoni ye-thyroid mhlawumbi yeyona hormone ibalulekileyo emzimbeni, ekuthiwa ilawula yonke imisebenzi ebalulekileyo kunye neemvakalelo zokuphila.
Isishwankathelo
Ihomoni yegilo ithathwa ngabanye ‘njengehomoni enkulu’ yomzimba kwaye imveliso ixhomekeke ikakhulu kwidlala lengqula nesibindi.
Ihomoni yegilo esebenzayo ivuselela ukuveliswa kwamandla e-mitochondrial, ukwakheka kwe-mitochondria eninzi, kunye neehomoni ze-steroid.
I-Hypothyroidism yimeko yamandla eselula aphantsi aneempawu ezininzi.
Iimbangela ze-thyroid ephantsi zinzima, ezinxulumene nokutya kunye nendlela yokuphila.
Ukutya okuphantsi kwe-carb kunye nomxholo ophezulu we-PUFA ekutyeni ngabaphuli-mthetho abaphambili, kunye noxinzelelo.
Idlala lengqulaunyango olulula?
Njengoko idlala lengqula libekwe phantsi kwesikhumba kunye namanqatha entamo, kufutshane ne-infrared lolona hlobo lufundwayo lokukhanya kunyango lwedlala lengqula.Oku kunengqiqo njengoko kungene kakhulu kunobomvu obubonakalayo (Kolari, 1985; Kolarova et al., 1999; Enwemeka, 2003, Bjordal JM et al., 2003).Nangona kunjalo, ibomvu iphantsi kwi-wavelength njenge-630nm ifundelwe i-thyroid (i-Morcos N et al., 2015), njengoko i-gland engaphezulu.
Ezi zikhokelo zilandelayo zikholisa ukuthotyelwa kwizifundo:
I-infrared LEDs / laserskuluhlu lwe-700-910nm.
100mW/cm² okanye uxinano lwamandla olungcono
Ezi zikhokelo zisekelwe kumaza asebenzayo kwizifundo ezikhankanywe ngasentla, kunye nezifundo zokungena kwezicubu ezikhankanywe ngasentla.Ezinye zezinto ezichaphazela ukungena ziquka;ukubetha, amandla, ukuqina, ukudibana kwezicubu, i-polarization kunye nokuhambelana.Ixesha lesicelo lingancitshiswa ukuba ezinye izinto ziphuculwe.
Ngamandla afanelekileyo, izibane ze-infrared ze-LED zinokuchaphazela yonke i-thyroid gland, ngaphambili ukuya ngasemva.Ukukhanya okubomvu okubonakalayo entanyeni kuya kubonelela ngeenzuzo, nangona isixhobo esinamandla siya kufuneka.Oku kungenxa yokuba okubomvu okubonakalayo akungeneli kangako njengoko sele kukhankanyiwe.Njengoqikelelo olurhabaxa, i-90w + ii-LED ezibomvu (620-700nm) kufuneka zibonelele ngezibonelelo ezilungileyo.
Ezinye iintlobo zeiteknoloji yonyango olukhanyayonjengee-lasers zomgangatho ophantsi zilungile, ukuba unokuzifumana.I-Lasers ifundwa rhoqo kwiincwadi kune-LEDs, nangona kunjalo ukukhanya kwe-LED ngokuqhelekileyo kuthathwa njengelinganayo ekusebenzeni (Chaves ME et al., 2014. Kim WS, 2011. Min PK, 2013).
Izibane zobushushu, ii-incandescents kunye ne-infrared saunas azikho ngokoqobo ekuphuculeni izinga le-metabolic / hypothyroidism.Oku kungenxa ye-engile ebanzi ye-beam, ubushushu obugqithisileyo / ukungasebenzi kunye ne-spectrum eyinkcitho.
Okukwintsusa
Ukukhanya okubomvu okanye i-infraredukusuka kumthombo we-LED (i-600-950nm) ifundwa kwi-thyroid.
Amanqanaba e-hormone ye-thyroid ajongwa kwaye alinganiswe kwisifundo ngasinye.
Inkqubo ye-thyroid inzima.Ukutya kunye nendlela yokuphila kufuneka kujongwane nayo.
Unyango lokukhanya kwe-LED okanye i-LLLT ifundwe kakuhle kwaye iqinisekisa ukhuseleko oluphezulu.I-Infrared (700-950nm) ii-LEDs zithandwa kule ndawo, ubomvu obonakalayo bulungile.
Ixesha lokuposa: Sep-26-2022