Iingxaki ze-thyroid zixhaphakile kuluntu lwanamhlanje, zichaphazela bonke abantu besini nabadala ukuya kumanqanaba ahlukeneyo. Ukuxilongwa mhlawumbi kuphoswa rhoqo kunanoma yiyiphi na enye imeko kwaye unyango oluqhelekileyo/imiyalelo yeengxaki ze-thyroid zisemva kwamashumi eminyaka ukuqonda kwesayensi ngale meko.
Umbuzo esiza kuwuphendula kweli nqaku ngulo – Ngaba unyango olukhanyayo lunokudlala indima ekuthinteleni nasekunyangeni iingxaki ze-thyroid/i-metabolism ephantsi?
Xa sijonga iincwadi zesayensi siyabona ukubaunyango lokukhanyaImpembelelo ye-thyroid ekusebenzeni kwe-thyroid ifundwe izihlandlo ezininzi, ebantwini (umz. Höfling DB et al., 2013), iimpuku (umz. Azevedo LH et al., 2005), onogwaja (umz. Weber JB et al., 2014), phakathi kwabanye. Ukuqonda isizathu sokubaunyango lokukhanyaisenokuba nomdla, okanye ingabi nomdla, kwaba baphandi, kuqala kufuneka siqonde iziseko.
Intshayelelo
I-Hypothyroidism (i-thyroid ephantsi, i-thyroid engasebenzi kakuhle) kufuneka ithathwe njengengxaki ewela kuyo wonke umntu, kunokuba ibe yimeko emnyama okanye emhlophe ethwaxwa ngabantu abadala kuphela. Akukho mntu kuluntu lwanamhlanje onamanqanaba e-hormone ye-thyroid afanelekileyo (Klaus Kapelari et al., 2007. Hershman JM et al., 1993. JM Corcoran et al., 1977.). Ukongeza ekudidekeni, kukho izizathu kunye neempawu ezifanayo kunye neminye imiba emininzi ye-metabolic efana nesifo seswekile, isifo sentliziyo, i-IBS, i-cholesterol ephezulu, ukudakumba kunye nokulahleka kweenwele (Betsy, 2013. Kim EY, 2015. Islam S, 2008, Dorchy H, 1985.).
Ukuba 'ne-metabolism ecothayo' ngokwenene yinto efanayo ne-hypothyroidism, yiyo loo nto ihambelana nezinye iingxaki emzimbeni. Ifunyaniswa kuphela njenge-hypothyroidism yeklinikhi xa ifikelele kwinqanaba eliphantsi.
Ngamafutshane, i-hypothyroidism yimeko yokuveliswa kwamandla aphantsi emzimbeni wonke ngenxa yomsebenzi ophantsi wehomoni ye-thyroid. Izizathu eziqhelekileyo ziyinkimbinkimbi, kubandakanya izinto ezahlukeneyo zokutya kunye nendlela yokuphila ezifana noxinzelelo, ufuzo, ukwaluphala, amafutha amaninzi, ukutya iicarbohydrate eziphantsi, ukutya iikhalori eziphantsi, ukungalali ngokwaneleyo, utywala, kwanokuzivocavoca umzimba ngokugqithisileyo. Ezinye izinto ezifana notyando lokususa i-thyroid, ukutya i-fluoride, unyango olwahlukeneyo lwezonyango, njalo njalo zibangela i-hypothyroidism.
Unyango olulula olunokuba luncedo kubantu abane-thyroid ephantsi?
Ukukhanya okubomvu kunye ne-infrared (600-1000nm)isenokuba luncedo kwimetabolism emzimbeni kumanqanaba ahlukeneyo.
1. Ezinye izifundo zigqiba kwelokuba ukusebenzisa ukukhanya okubomvu ngokufanelekileyo kunokuphucula ukuveliswa kweehomoni. (Höfling et al., 2010,2012,2013. Azevedo LH et al., 2005. Вера Александровна, 2010. Gopkalova, I. 2010.) Njengazo naziphi na izicwili emzimbeni, i-thyroid gland ifuna amandla ukuze yenze yonke imisebenzi yayo. Njengoko i-thyroid hormone iyinxalenye ebalulekileyo ekuvuseleleni ukuveliswa kwamandla, ungabona indlela ukungabikho kwayo kwiiseli ze-thyroid okunciphisa ngayo ukuveliswa kweehomoni ze-thyroid - umjikelo onzima wesiqhelo. I-thyroid ephantsi -> amandla aphantsi -> i-thyroid ephantsi -> njl.
2. Unyango olukhanyayoXa isetyenziswe ngokufanelekileyo entanyeni isenokuwuqhawula lo mjikelo unzima, ngokwethiyori ngokuphucula ukufumaneka kwamandla asekuhlaleni, ngaloo ndlela inyusa ukuveliswa kwehomoni ye-thyroid yendalo yi-gland kwakhona. Xa i-thyroid gland esempilweni ibuyiselwe, kuvela iziphumo ezininzi ezilungileyo, njengoko umzimba wonke ekugqibeleni ufumana amandla owadingayo (Mendis-Handagama SM, 2005. Rajender S, 2011). Ukwenziwa kwehomoni ye-steroid (testosterone, progesterone, njl.njl.) kuyaphinda kuqalise - imood, libido kunye namandla ziyaphucuka, ubushushu bomzimba buyanda kwaye ngokusisiseko zonke iimpawu ze-metabolism ephantsi ziyaguqulwa (Amy Warner et al., 2013) - kwanembonakalo yomzimba kunye nomtsalane wesondo kuyanda.
3. Kunye neenzuzo ezinokubakho emzimbeni ezivela ekuvezweni yi-thyroid, ukusebenzisa ukukhanya naphi na emzimbeni kunokunika iziphumo zomzimba, ngegazi (Ihsan FR, 2005. Rodrigo SM et al., 2009. Leal Junior EC et al., 2010). Nangona iiseli ezibomvu zegazi zingenazo i-mitochondria; iiplatelets zegazi, iiseli ezimhlophe zegazi kunye nezinye iintlobo zeeseli ezikhoyo egazini ziqulathe i-mitochondria. Oku kukodwa kuyafundwa ukuze kubonwe indlela kunye nesizathu sokuba kunokunciphisa ukudumba kunye namanqanaba e-cortisol - i-hormone yoxinzelelo ethintela ukusebenza kwe-T4 -> T3 (Albertini et al., 2007).
4. Ukuba umntu ebenokufaka ukukhanya okubomvu kwiindawo ezithile zomzimba (ezifana nengqondo, ulusu, amasende, amanxeba, njl.njl.), abanye abaphandi bacinga ukuba mhlawumbi kunokunika amandla angakumbi kwindawo ethile. Oku kuboniswa ngcono zizifundo zonyango lokukhanya kwiingxaki zesikhumba, amanxeba kunye nosulelo, apho kwizifundo ezahlukeneyo ixesha lokuphiliswa linokuncipha ngenxaukukhanya okubomvu okanye kwe-infrared(J. Ty Hopkins et al., 2004. Avci et al., 2013, Mao HS, 2012. Percival SL, 2015. da Silva JP, 2010. Gupta A, 2014. Güngörmüş M, 2009). Isiphumo sokukhanya sendawo sinokubonakala ngathi sahlukile kodwa sihambelana nomsebenzi wendalo wehomoni ye-thyroid.
Ithiyori eqhelekileyo neyamkelweyo ngokubanzi yempembelelo ethe ngqo yonyango lokukhanya ibandakanya ukuveliswa kwamandla eeseli. Iziphumo kuthiwa zenziwa ikakhulu yi-photodissociating nitric oxide (NO) kwi-enzymes ze-mitochondrial (i-cytochrome c oxidase, njl.njl.). Ungacinga nge-NO njengomncintisani onobungozi kwioksijini, njengokuba injalo i-carbon monoxide. I-NO ngokusisiseko iyayivala imveliso yamandla kwiiseli, yenze indawo echitha kakhulu amandla, nto leyo enyusa i-cortisol/uxinzelelo.Ukukhanya okubomvuithiwa kukuthintela le nitric oxide poison, kunye noxinzelelo oluvela kuyo, ngokuyisusa kwi-mitochondria. Ngale ndlela ukukhanya okubomvu kunokucingelwa 'njengokuchasa uxinzelelo', endaweni yokonyusa imveliso yamandla ngoko nangoko. Kukuvumela nje i-mitochondria yeeseli zakho ukuba isebenze ngokufanelekileyo ngokunciphisa iziphumo zokunciphisa uxinzelelo, ngendlela i-thyroid hormone yodwa engenzi ngayo.
Nangona i-thyroid hormone iphucula inani kunye nokusebenza kakuhle kwe-mitochondria, ingcamango ejikeleze unyango lokukhanya kukuba inokuphucula kwaye iqinisekise iziphumo ze-thyroid ngokuthintela iimolekyuli ezingalunganga ezinxulumene noxinzelelo. Kusenokubakho ezinye iindlela ezininzi ezingathanga ngqo apho zombini i-thyroid kunye nokukhanya okubomvu kunciphisa uxinzelelo, kodwa asizukuthetha ngazo apha.
Iimpawu zesantya esiphantsi se-metabolic rate/hypothyroidism
Intliziyo ebetha kancinci (ngaphantsi kwe-75 bpm)
Ubushushu bomzimba obuphantsi, ngaphantsi kwama-98°F/36.7°C
Soloko uziva ubanda (ingakumbi izandla neenyawo)
Ulusu olomileyo naphi na emzimbeni
Iingcinga ezinomsindo/ezinomoya wokucaphuka
Ukuziva uxinezelekile/uxhalabile
Inkungu yobuchopho, iintloko ezibuhlungu
Iinwele/izinzipho ezikhula kancinci
Iingxaki zamathumbu (ukuqunjelwa, isifo sohudo, i-IBS, i-SIBO, ukudumba, isitshiso sentliziyo, njl.njl.)
Ukuchama rhoqo
Ukungakwazi ukuzibandakanya ngesondo okuphantsi/okungekhoyo (kunye/okanye ukungakwazi ukuqina/ukungathambisa kakuhle kwelungu lobufazi)
Ukuchaphazeleka kwemvubelo/i-candida
Umjikelo wokuya exesheni ongahambelaniyo, onzima, obuhlungu
Ukungazali
Iinwele ezinciphayo/ezibuya ngokukhawuleza. Amashiya anciphayo
Ubuthongo obubi
Isebenza njani inkqubo ye-thyroid?
Ihomoni ye-thyroid iqala iveliswe kwi-thyroid gland (ekwintamo) njenge-T4, ize ihambe ngegazi iye kwisibindi nakwezinye izicwili, apho iguqulwa ibe yimo esebenzayo ngakumbi - i-T3. Olu hlobo lwehomoni ye-thyroid olusebenzayo ngakumbi luhamba luye kuyo yonke iseli yomzimba, lusebenza ngaphakathi kwiiseli ukuphucula imveliso yamandla eseli. Ngoko ke i-thyroid gland -> isibindi -> zonke iiseli.
Yintoni edla ngokungahambi kakuhle kule nkqubo yokuvelisa? Kwikhonkco lomsebenzi wehomoni ye-thyroid, naliphi na icala linokubangela ingxaki:
1. I-thyroid gland ngokwayo ayinakuvelisa iihomoni ezaneleyo. Oku kusenokuba kubangelwa kukungabikho kwe-iodine ekutyeni, ubuninzi be-polyunsaturated fatty acids (PUFA) okanye i-goitrogens ekutyeni, utyando lwe-thyroid lwangaphambili, into ebizwa ngokuba yi-'autoimmune' imeko kaHashimoto, njl.
2. Isibindi asinakuba 'sivuselela' iihomoni (T4 -> T3), ngenxa yokunqongophala kweglucose/glycogen, i-cortisol egqithisileyo, umonakalo wesibindi obangelwa kukutyeba kakhulu, utywala, iziyobisi kunye nosulelo, isinyithi esigqithisileyo, njl.njl.
3. Iiseli zisenokungazifunxi iihomoni ezikhoyo. Ukufunxwa kweeseli kwehomoni esebenzayo ye-thyroid kudla ngokuba ngenxa yezinto zokutya. Amafutha e-polyunsaturated avela ekutyeni (okanye kumafutha agciniweyo akhutshwa ngexesha lokunciphisa umzimba) athintela ihomoni ye-thyroid ukuba ingangeni kwiiseli. I-glucose, okanye iiswekile ngokubanzi (i-fructose, i-sucrose, i-lactose, i-glycogen, njl.njl.), zibalulekile ekufunxweni nasekusetyenzisweni kwehomoni esebenzayo ye-thyroid ziiseli.
Ihomoni ye-thyroid kwiseli
Ukuba akukho mqobo ukhoyo kwimveliso yehomoni ye-thyroid, kwaye inokufikelela kwiiseli, isebenza ngokuthe ngqo nangokungathanga ngqo kwinkqubo yokuphefumla kwiiseli - okukhokelela ekufakweni ngokupheleleyo kweglucose (kwi-carbon dioxide). Ngaphandle kwehomoni ye-thyroid eyaneleyo 'yokudibanisa' iiproteni ze-mitochondrial, inkqubo yokuphefumla ayinakuphelela kwaye idla ngokuphumela kwi-lactic acid endaweni yesiphumo sokugqibela sekhabhoni dioxide.
Ihomoni ye-thyroid isebenza kwi-mitochondria nakwi-nucleus yeeseli, ibangela iziphumo zexesha elifutshane nezexesha elide eziphucula imetabolism ye-oxidative. Kwi-nucleus, i-T3 kucingelwa ukuba inefuthe ekubonakalisweni kwezakhi ezithile zemfuza, okukhokelela kwi-mitochondria engaphezulu/entsha. Kwi-mitochondria esele ikho, inefuthe lokuphucula amandla ngokuthe ngqo nge-cytochrome oxidase, kunye nokukhupha ukuphefumla okuvela kwimveliso ye-ATP.
Oku kuthetha ukuba i-glucose inokutyhalelwa kwindlela yokuphefumla ngaphandle kokuba kufuneke ivelise i-ATP. Nangona oku kunokubonakala ngathi kuchitha imali, kunyusa ubungakanani be-carbon dioxide eluncedo, kwaye kuyeke ukuba i-glucose igcinwe njenge-lactic acid. Oku kunokubonwa ngakumbi kubantu abanesifo seswekile, abadla ngokufumana amanqanaba aphezulu e-lactic acid ekhokelela kwimeko ebizwa ngokuba yi-lactic acidosis. Abantu abaninzi abane-hypothyroidism bade bavelise i-lactic acid ebalulekileyo xa bephumle. I-thyroid hormone idlala indima ethe ngqo ekunciphiseni le meko inobungozi.
Ihomoni ye-thyroid inomsebenzi omnye emzimbeni, idibene ne-vitamin A kunye ne-cholesterol ukwenza i-pregnenolone - into eyandulela zonke iihomoni ze-steroid. Oku kuthetha ukuba amanqanaba aphantsi e-thyroid ngokungenakuphepheka abangela amanqanaba aphantsi e-progesterone, i-testosterone, njl. Amanqanaba aphantsi e-bile salts nawo aya kwenzeka, ngaloo ndlela ethintela ukugaya ukutya. Ihomoni ye-thyroid mhlawumbi yeyona homoni ibalulekileyo emzimbeni, ekuthiwa ilawula yonke imisebenzi ebalulekileyo kunye neemvakalelo zempilo.
Isishwankathelo
Ihomoni ye-thyroid ithathwa ngabanye njenge-'hormone eyintloko' yomzimba kwaye imveliso ixhomekeke kakhulu kwi-thyroid gland nakwisibindi.
I-hormone ye-thyroid esebenzayo ivuselela ukuveliswa kwamandla e-mitochondrial, ukwakheka kwee-mitochondria ezingaphezulu, kunye nee-steroid hormones.
I-Hypothyroidism yimeko apho amandla eeseli aphantsi eneempawu ezininzi.
Izizathu zokuba i-thyroid ingabi namandla zintsonkothile, zinxulumene nokutya nendlela yokuphila.
Ukutya okune-carbohydrate ephantsi kunye nomxholo ophezulu we-PUFA ekutyeni zezona zinto ziphambili ezibangela uxinezeleko.
I-thyroidunyango lokukhanya?
Njengoko i-thyroid gland ikwindawo engaphantsi kwesikhumba namafutha entanyeni, kufutshane ne-infrared lolona hlobo lokukhanya olufundwa kakhulu kunyango lwe-thyroid. Oku kunengqiqo kuba lungena kakhulu kunobomvu obubonakalayo (Kolari, 1985; Kolarova et al., 1999; Enwemeka, 2003, Bjordal JM et al., 2003). Nangona kunjalo, ubomvu obuphantsi kobude be-630nm bufundwe kwi-thyroid (Morcos N et al., 2015), njengoko liyi-gland engaphezulu.
Ezi zikhokelo zilandelayo zihlala zilandelwa kwizifundo:
Ii-LED/iileser ze-infraredkuluhlu lwe-700-910nm.
Uxinano lwamandla olungcono yi-100mW/cm² okanye ngaphezulu
Ezi zikhokelo zisekelwe kubude be-wavelengths obusebenzayo kwizifundo ezikhankanyiweyo apha ngasentla, kunye nezifundo zokungena kwezicubu ezikhankanyiweyo apha ngasentla. Ezinye zezinto ezichaphazela ukungena ziquka; ukutyhala, amandla, ubukhali, ukudibana kwezicubu, ukuqhekeka kunye nokuhambelana. Ixesha lokusetyenziswa lingancitshiswa ukuba ezinye izinto ziphuculwe.
Ngamandla afanelekileyo, izibane ze-infrared LED zinokuchaphazela yonke i-thyroid gland, ukusuka ngaphambili ukuya ngasemva. Ukukhanya okubomvu okubonakalayo entanyeni nako kuya kubonelela ngeenzuzo, nangona kuya kufuneka isixhobo esomeleleyo. Oku kungenxa yokuba ubomvu obubonakalayo abungeni kangako njengoko sele kukhankanyiwe. Njengoqikelelo oluqikelelweyo, ii-LED ezibomvu ezingama-90w+ (620-700nm) kufuneka zibonelele ngeenzuzo ezilungileyo.
Ezinye iintlobo zeiteknoloji yonyango lokukhanyanjengeeleser ezikumgangatho ophantsi zilungile, ukuba unako ukuzihlawulela. Iileser zifundwa rhoqo kwiincwadi kuneeLED, nangona kunjalo ukukhanya kwe-LED kudla ngokuthathwa njengokulinganayo ngokusebenza (Chaves ME et al., 2014. Kim WS, 2011. Min PK, 2013).
Izibane zobushushu, ii-incandescent kunye nee-infrared saunas aziluncedo kangako ekuphuculeni izinga le-metabolism / i-hypothyroidism. Oku kungenxa ye-wide beam angle, ubushushu obugqithisileyo/ukungasebenzi kakuhle kunye ne-spectrum echitha imali.
Okukwintsusa
Ukukhanya okubomvu okanye kwe-infraredkufunyenwe umthombo we-LED (600-950nm) kwi-thyroid.
Amanqanaba e-hormone ye-thyroid ajongwa kwaye alinganiswa kwisifundo ngasinye.
Inkqubo ye-thyroid iyinkimbinkimbi. Ukutya kunye nendlela yokuphila nazo kufuneka ziqwalaselwe.
Unyango lokukhanya kwe-LED okanye i-LLLT lufundwe kakuhle kwaye luqinisekisa ukhuseleko oluphezulu. Ii-LED ze-infrared (700-950nm) ziyathandwa kweli candelo, ubomvu obubonakalayo bulungile.