Isifo sika-Alzheimer, isifo esiqhubekayo sokuwohloka kwemithambo-luvo, sibonakala ngeempawu ezifana nokulahlekelwa yinkumbulo, i-aphasia, i-agnosia, kunye nokusebenza kakubi kwamandla. Ngokwesiko, izigulana bezixhomekeke kumayeza okuphelisa iimpawu. Nangona kunjalo, ngenxa yemida kunye nemiphumo emibi enokubakho yala mayeza, abaphandi baye bajika ingqalelo yabo kwi-phototherapy engangenisi ntsholongwane, bafumana impumelelo ebalulekileyo kwiminyaka yakutshanje.
Kutshanje, iqela elikhokelwa nguNjingalwazi uZhou Feifan kwiKholeji yoBunjineli beBiomedical kwiYunivesithi yaseHainan lifumanise ukuba unyango olungena-contact transcranial phototherapy lunokunciphisa iimpawu ze-pathological kwaye luphucule ubuchule bokuqonda kwiimpuku ezindala nezine-Alzheimer's. Olu phando lubalaseleyo, olupapashwe kwijenali i-Nature Communications, lubonelela ngesicwangciso esithembisayo sokulawula izifo ze-neurodegenerative.
Ukuqonda i-Alzheimer's Disease Pathology
Isizathu esichanekileyo se-Alzheimer's asikacaci, kodwa sibonakala ngokuqokelelwa kweproteni ye-beta-amyloid engaqhelekanga kunye nokuxinana kwe-neurofibrillary, okukhokelela ekungasebenzi kakuhle kwe-neuronal kunye nokuwohloka kwengqondo. Ingqondo, njengelungu elisebenzayo kakhulu emzimbeni, ivelisa inkunkuma ebalulekileyo ye-metabolic ngexesha lomsebenzi we-neural. Ukuqokelelwa kakhulu kwale nkunkuma kungonakalisa ii-neurons, nto leyo ebangela ukuba kususwe ngokufanelekileyo kwinkqubo ye-lymphatic.
Imithambo ye-meningeal lymphatic, ebaluleke kakhulu ekukhupheni amanzi kwinkqubo yemithambo-luvo ephakathi, idlala indima ebalulekileyo ekususeni iiproteni ze-beta-amyloid ezinobuthi, inkunkuma ye-metabolic, kunye nokulawula ukusebenza komzimba, nto leyo eyenza ukuba ibe yindawo ekujoliswe kuyo kunyango.
Impembelelo yePhototherapy kwi-Alzheimer's
Iqela likaNjingalwazi uZhou lisebenzise i-laser ye-808 nm ekufutshane ne-infrared kangangeeveki ezine ze-non-contact transcranial phototherapy kwiimpuku ezindala kunye ne-Alzheimer's. Olu nyango luphucule kakhulu ukusebenza kweeseli ze-meningeal lymphatic endothelial, lwaphucula ukuphuma kwamanzi emzimbeni, kwaye ekugqibeleni lwanciphisa iimpawu zesifo kunye nokusebenza kwengqondo okuphuculweyo kwiimpuku.
Ukukhuthaza Umsebenzi Wee-Neuronal nge-Phototherapy
I-Phtotherapy inokuphucula kwaye iphucule ukusebenza kwe-neuronal ngeendlela ezahlukeneyo. Umzekelo, inkqubo yokuzikhusela komzimba idlala indima ebalulekileyo kwi-Alzheimer's pathology. Izifundo zakutshanje zibonisa ukuba i-532 nm green laser irradiation inokunyusa ukusebenza kwe-immune cell, ibangele iindlela zangaphakathi kwi-neurons ephakathi, iphucule i-vascular dementia, kwaye iphucule ukuhamba kwegazi kunye neempawu zonyango kwizigulane ze-Alzheimer's. I-green laser vascular irradiation yokuqala ibonise ukuphucuka okukhulu kwi-viscosity yegazi, i-plasma viscosity, i-red blood cell aggregation, kunye novavanyo lwe-neuropsychological.
Unyango olubomvu nolwe-infrared light (photobiomodulation) olusetyenziswa kwiindawo zomzimba ezingaphandle (emqolo nasemilenzeni) lunokuvuselela iiseli zomzimba okanye iindlela zokukhusela iiseli ze-stem, nto leyo enegalelo ekusindeni kwee-neuron kunye nokubonakaliswa kwezakhi zofuzo okuluncedo.
Umonakalo we-oxidative ukwayindlela ebalulekileyo ye-pathological kuphuhliso lwe-Alzheimer's. Uphando lubonisa ukuba ukukhanya okubomvu kunokunyusa umsebenzi we-ATP weseli, kubangele utshintsho lwe-metabolic ukusuka kwi-glycolysis ukuya kumsebenzi we-mitochondrial kwi-inflammatory microglia echaphazelekayo yi-oligomeric beta-amyloid, kuphuculwe amanqanaba e-anti-inflammatory microglia, kuncitshiswe ii-cytokines ezibangela ukuvuvukala, kwaye kusebenze i-phagocytosis ukuthintela ukufa kwe-neuronal.
Ukuphucula ukuphaphama, ukuqonda, kunye nokufumana ingqalelo eqhubekayo yenye indlela efanelekileyo yokuphucula umgangatho wobomi bezigulane ze-Alzheimer. Abaphandi bafumanise ukuba ukuchacha kukukhanya okuluhlaza okwesibhakabhaka okufutshane kuchaphazela kakuhle ukusebenza kwengqondo kunye nokulawulwa kweemvakalelo. Ukukhanya okuluhlaza okwesibhakabhaka kunokukhuthaza umsebenzi wesekethe yemithambo-luvo, kuchaphazele umsebenzi we-acetylcholinesterase (AchE) kunye ne-choline acetyltransferase (ChAT), ngaloo ndlela kuphucula ubuchule bokufunda kunye nokukhumbula.
Iziphumo Ezintle Ze-Phototherapy Kwi-Brain Neurons
Uphando olukhulayo olunegunya luqinisekisa iziphumo ezilungileyo ze-phototherapy ekusebenzeni kwee-neuron zobuchopho. Inceda ekusebenzeni kweendlela zokukhusela zangaphakathi zeeseli zomzimba, ikhuthaza ukubonakaliswa kwezakhi zofuzo zokusinda kwe-neuronal, kwaye ilinganise amanqanaba e-oksijini esebenzayo kwi-mitochondrial. Ezi ziphumo ziseka isiseko esiqinileyo sezicelo zonyango ze-phototherapy.
Ngokusekelwe kwezi mbono, i-MERICAN Optical Energy Research Center, ngokubambisana neqela laseJamani kunye neeyunivesithi ezininzi, uphando, kunye namaziko ezonyango, yenze uphando olubandakanya abantu abaneminyaka engama-30-70 abanengxaki yokuqonda kancinci, ukuwohloka kwenkumbulo, ukuqonda okuncinci kunye nokugweba, kunye nokukwazi ukufunda okuncinci. Abathathi-nxaxheba balandele izikhokelo zokutya kunye nendlela yokuphila enempilo ngelixa befumana unyango lwe-phototherapy kwigumbi lezempilo laseMERICAN, kunye neentlobo zamayeza ezihambelanayo kunye needosi.
Emva kweenyanga ezintathu zovavanyo lwe-neuropsychological, uvavanyo lwemeko yengqondo, kunye novavanyo lwengqondo, iziphumo zibonise ukuphucuka okukhulu kumanqaku e-MMSE, ADL, kunye ne-HDS phakathi kwabasebenzisi be-phototherapy yekhabhini yezempilo. Abathathi-nxaxheba baphinde bafumana ingqalelo ephuculweyo yokubona, umgangatho wokulala, kunye nokuncipha kwexhala.
Ezi ziphumo zibonisa ukuba i-phototherapy ingasebenza njengonyango oluxhasayo lokulawula umsebenzi weeseli zobuchopho, ukunciphisa ukudumba kwe-neuroinflammation kunye nezifo ezinxulumene noko, ukuphucula ukuqonda, kunye nokuphucula inkumbulo. Ngaphezu koko, ivula iindlela ezintsha zokuba i-phototherapy iguqukele kwindlela yokuthintela unyango.
