Isifo se-Alzheimer's, i-progressive neurodeergenerative disorder, ibonakalisa ngeempawu ezifana nokulahlekelwa kwememori, i-aphasia, i-agnosia, kunye nokungasebenzi kakuhle kwesigqeba. Ngokwesiko, izigulane ziye zathembela kumayeza ukuthomalalisa iimpawu. Nangona kunjalo, ngenxa yokusikelwa umda kunye nemiphumo enokubakho yala machiza, abaphandi baye bajika ingqalelo yabo kwi-phototherapy engabonakaliyo, ukuphumeza impumelelo ebalulekileyo kwiminyaka yamuva.
Kutshanje, iqela elikhokelwa nguNjingalwazi uZhou Feifan ovela kwiKholeji yobuNjineli beBiomedical yeYunivesithi yaseHainan yafumanisa ukuba i-phototherapy ye-non-contact transcranial inokunciphisa iimpawu ze-pathological kwaye ikhulise amandla okuqonda kumagundane asele ekhulile kunye ne-Alzheimer's. Oku kufunyanisiweyo okusisiseko, okupapashwe kwijenali yoNxibelelwano lweNdalo, inika isicwangciso esithembisayo sokulawula izifo ze-neurodeergenerative.
Ukuqonda i-Alzheimer's Disease Pathology
Oyena nobangela we-Alzheimer's uhlala ungacacanga, kodwa ubonakaliswa ngokungaqhelekanga kwe-beta-amyloid protein aggregation kunye ne-neurofibrillary tangles, ekhokelela kukungasebenzi kakuhle kwe-neuronal kunye nokuncipha kwengqondo. Ingqondo, njengelona lungu lomzimba elisebenza kakhulu kwimetabolism, ivelisa inkunkuma ebalulekileyo ye-metabolic ngexesha lomsebenzi we-neural. Ukuqokelela okugqithisileyo kwale nkunkuma kunokonakalisa i-neurons, kufuneke ukuba kususwe ngokufanelekileyo ngenkqubo ye-lymphatic.
Iinqanawa ze-meningeal lymphatic, ezibaluleke kakhulu kwi-drainage ye-nervous system drainage, zidlala indima ephambili ekucoceni iiprotheni ze-beta-amyloid ezinobuthi, inkunkuma ye-metabolic, kunye nokulawula umsebenzi wokuzivikela komzimba, okwenza kube yinto ekujoliswe kuyo kunyango.
Impembelelo ye-Phototherapy kwi-Alzheimer's
Iqela likaNjingalwazi uZhou lisebenzise i-808 nm kufuphi ne-laser ye-infrared kwiiveki ezine ze-non-contact transcranial phototherapy kubantu abadala kunye neempuku ze-Alzheimer. Olu nyango luwuphucule kakhulu umsebenzi weeseli ze-meningeal lymphatic endothelial, uphuculo lwe-lymphatic drainage, kwaye ekugqibeleni lwathomalalisa iimpawu ze-pathological kunye nokuphucula imisebenzi yokuqonda kwiimpuku.
Ukukhuthaza i-Neuronal Function ngokusebenzisa i-Phototherapy
I-Ptotherapy inokuphucula kunye nokuphucula umsebenzi we-neuronal ngokusebenzisa iindlela ezahlukeneyo. Umzekelo, inkqubo yomzimba yokuzikhusela idlala indima ebalulekileyo kwi-Alzheimer's pathology. Uphononongo lwakutsha nje lubonisa ukuba i-532 nm ye-laser irradiation eluhlaza inokunyusa ukusebenza kweeseli zomzimba, ibangele iindlela zangaphakathi kwi-neuron enzulu ephakathi, ukuphucula ukudemeka kwemithambo, kunye nokuphucula ukuhamba kwegazi kunye neempawu zekliniki kwizigulana ze-Alzheimer's. I-laser eluhlaza irradiation yokuqala ibonise ukuphucuka okubalulekileyo kwi-viscosity yegazi, i-plasma viscosity, i-red blood aggregation, kunye novavanyo lwe-neuropsychological.
Unyango olubomvu kunye nokukhanya kwe-infrared (photobiomodulation) esetyenziswa kwiindawo ezijikelezayo zomzimba (umva kunye nemilenze) inokusebenzisa iiseli ze-immune okanye iiseli ze-stem 'iindlela zokukhusela ezingaphakathi, ezinegalelo ekusindeni kwe-neuronal kunye nokubonakaliswa kwe-gene enenzuzo.
Umonakalo we-oxidative kwakhona yinkqubo ebalulekileyo ye-pathological kuphuhliso lwe-Alzheimer. Uphando lubonisa ukuba ukukhanya okubomvu kunokunyusa umsebenzi we-ATP yeselula, kubangele utshintsho lwe-metabolic ukusuka kwi-glycolysis ukuya kumsebenzi we-mitochondrial kwi-microglia evuthayo echatshazelwa yi-oligomeric beta-amyloid, ukuphucula amanqanaba e-microglia e-anti-inflammatory, ukunciphisa i-cytokines e-pro-inflammatory, kunye nokusebenzisa i-phagocytosis ukukhusela i-neuronal. ukufa.
Ukuphucula ukuphaphama, ukuqonda, kunye nengqalelo ezinzileyo yenye indlela esebenzayo yokuphucula umgangatho wobomi bezigulane ze-Alzheimer. Abaphandi bafumanise ukuba ukuvezwa kukukhanya okufutshane nobude obuluhlaza okwesibhakabhaka kunempembelelo entle ekusebenzeni kwengqondo kunye nolawulo lweemvakalelo. I-irradiation eluhlaza okwesibhakabhaka inokukhuthaza umsebenzi wesiphaluka se-neural, ifuthe umsebenzi we-acetylcholinesterase (AchE) kunye ne-choline acetyltransferase (Chat), ngaloo ndlela iphucula amandla okufunda kunye nokukhumbula.
I-Phototherapy yeziphumo ezilungileyo kwi-Brain Neurons
Umzimba okhulayo wophando olugunyazisiweyo uqinisekisa iziphumo ezilungileyo ze-phototherapy ekusebenzeni kwe-brain neuron. Inceda ukwenza kusebenze iindlela zokukhusela ezingaphakathi kwiiseli ze-immune, ikhuthaza ukusinda kwi-neuronal gene expression, kunye nokulinganisa amanqanaba eentlobo ze-oksijini esebenzayo ye-mitochondrial. Ezi ziphumo zenza isiseko esiluqilima kwizicelo zeklinikhi zefototherapy.
Ngokusekelwe kwezi ngcamango, i-MERICAN Optical Energy Research Centre, ngokubambisana neqela laseJamani kunye neeyunivesithi ezininzi, uphando, kunye namaziko ezonyango, lenze uphando olubandakanya abantu abaneminyaka eyi-30-70 kunye nokuphazamiseka kwengqondo okuncinci, ukuncipha kwememori, ukunciphisa ukuqonda kunye nokugweba, kunye nokuncipha kwamandla okufunda. Abathathi-nxaxheba babambelele kwimigaqo yokutya kunye nendlela yokuphila enempilo ngelixa besenza i-phototherapy kwikhabhinethi yezempilo ye-MERICAN, kunye neentlobo zamayeza angaguqukiyo kunye needosi.
Emva kweenyanga ezintathu zeemvavanyo ze-neuropsychological, iimviwo zengqondo, kunye nokuhlolwa kwengqondo, iziphumo zibonise ukuphuculwa okuphawulekayo kwi-MMSE, i-ADL, kunye ne-HDS amanqaku phakathi kwabasebenzisi be-cabin phototherapy yezempilo. Abathathi-nxaxheba baye bafumana ingqwalasela eyongeziweyo yokubonwayo, umgangatho wokulala, kunye nokunciphisa ixhala.
Ezi ziphumo zibonisa ukuba i-phototherapy inokusebenza njengonyango oluxhasayo ukulawula ukusebenza kweeseli zengqondo, ukunciphisa i-neuroinflammation kunye ne-pathologies ehambelanayo, ukuphucula ukuqonda, kunye nokuphucula imemori. Ngaphezu koko, ivula iindlela ezintsha zokuba i-phototherapy iguquke ibe yindlela yokuthintela unyango.
