Ukukhanya kwimiphetho ebomvu nekufutshane ne-infrared ye-spectrum kukhawulezisa ukuphiliswa kuzo zonke iiseli kunye nezicubu. Enye yeendlela abaphumeza ngayo oku kukusebenza njengee-antioxidants ezinamandla. Zikwathintela ukuveliswa kwe-nitric oxide.
Ngaba ukukhanya okubomvu nokukufutshane ne-infrared kungathintela okanye kubuyisele umva?
Kwisifundo sowama-2016, abaphandi basebenzise ukukhanya okukufutshane ne-infrared kwiiseli zokuva kwi-vitro ngaphambi kokuba bazibeke phantsi koxinzelelo lwe-oxidative ngokuzibeka kwiityhefu ezahlukeneyo. Emva kokubeka iiseli ezilungisiweyo kwityhefu ye-chemotherapy kunye ne-endotoxin kwiiseli ezilungisiweyo, abaphandi bophando bafumanise ukuba ukukhanya kutshintshe imetabolism ye-mitochondrial kunye nempendulo yoxinzelelo lwe-oxidative ukuya kuthi ga kwiiyure ezingama-24 emva konyango.
“Sixela ukwehla kwee-cytokines ezivuthayo kunye namanqanaba oxinzelelo avela kwi-NIR esetyenziswa kwiiseli zokuva ze-HEI-OC1 ngaphambi konyango nge-gentamicin okanye i-lipopolysaccharide,” babhale ababhali bolu phando.
Iziphumo zophando zibonise ukuba unyango lwangaphambi konyango olune-infrared light lunciphise iimpawu zokudumba ezinxulunyaniswa nokwanda kweentlobo zeoksijini ezisabelayo kunye ne-nitric oxide.
Isifundo #1: Ngaba ukukhanya okuBomvu kungaguqula ukulahleka kokuva?
Isiphumo sokukhanya okukufutshane ne-infrared ekulahlekelweni kokuva emva kokutyhefwa yi-chemotherapy sivavanyiwe. Ukuva kuhlolwe emva kokunikwa i-gentamicin kwaye kwakhona emva kweentsuku ezili-10 zonyango lokukhanya.
Xa kuskenwa imifanekiso ye-electron microscopic, "i-LLLT yonyuse kakhulu inani leeseli zeenwele ezikwiindlela eziphakathi nezisezantsi. Ukuva kuphuculwe kakhulu yi-laser irradiation. Emva konyango lwe-LLLT, zombini umda wokuva kunye nenani leeseli zeenwele liphucuke kakhulu."
Isifundo #2: Ngaba ukukhanya okuBomvu kungaguqula ukulahleka kokuva?
Kolu phononongo, iimpuku zazivezwa yingxolo enkulu kuzo zombini iindlebe. Emva koko, iindlebe zazo zasekunene zanikwa ukukhanya okukufutshane ne-infrared kangangemizuzu engama-30 yonyango imihla ngemihla kangangeentsuku ezi-5.
Ukulinganiswa kwempendulo ye-brainstem yokuva kubonise ukubuyiselwa ngokukhawuleza komsebenzi wokuva kumaqela anyangwe nge-LLLT xa kuthelekiswa neqela elinganyangwanga kwiintsuku 2, 4, 7 kunye ne-14 emva kokuvezwa yingxolo. Ukuhlolwa kwesimo somzimba kukwabonise izinga eliphezulu kakhulu lokusinda kweeseli zeenwele zangaphandle kumaqela e-LLLT.
Bekhangela izalathisi zoxinzelelo lwe-oxidative kunye ne-apoptosis kwiiseli ezinganyangwanga xa kuthelekiswa nezo zinyangiweyo, abaphandi bafumanise ukuba “Ii-immunoreactivities ezinamandla zibonwe kwizicubu zendlebe zangaphakathi zeqela elinganyangwanga, ngelixa ezi zimpawu zincitshisiwe kwiqela le-LLLT kubuninzi bamandla obuyi-165mW/cm(2).”
"Iziphumo zethu zibonisa ukuba i-LLLT inefuthe lokukhusela i-NIHL ngokuthintela ukubonakaliswa kwe-iNOS kunye ne-apoptosis."
Isifundo #3: Ngaba ukukhanya okubomvu kungaguqula ukulahleka kokuva?
Kwisifundo sowama-2012, iimpuku ezilithoba zavezwa kwingxolo enkulu kwaye kwavavanywa ukusetyenziswa kokukhanya okukufutshane ne-infrared ekubuyiseleni ukuva. Ngosuku olulandelayo emva kokuvezwa kwingxolo enkulu, iindlebe zasekhohlo zeimpuku zanyangwa ngokukhanya okukufutshane ne-infrared imizuzu engama-60 kangangeentsuku ezili-12 zilandelelana. Iindlebe zasekunene azizange zinyangwe kwaye zathathwa njengeqela lolawulo.
“Emva kokukhanya kwe-12, umda wokuva wawuphantsi kakhulu kwiindlebe zasekhohlo xa kuthelekiswa neendlebe zasekunene.” Xa kujongwa kusetyenziswa imakroskopu ye-electron, inani leeseli zeenwele ezivayo kwiindlebe ezinyangiweyo lalilikhulu kakhulu kunelo leendlebe ezinganyangwanga.
"Iziphumo zethu zibonisa ukuba i-laser radiation ephantsi ikhuthaza ukubuyiselwa kwemingcele yokuva emva kokwenzakala okukhulu kwe-acoustic."