UNyango lwesibane esiBomvu vs iLahleko yokuva

Ukukhanya kwiiphelo ezibomvu kunye ne-infrared ezikufutshane ze-spectrum zikhawuleza ukuphilisa kuzo zonke iiseli kunye nezicubu.Enye yeendlela abaphumeza ngazo oku kukusebenza njengama-antioxidants anamandla.Kananjalo zithintela ukuveliswa kwe-nitric oxide.

Ngaba ukukhanya okubomvu kunye nekufutshane ne-infrared kungakuthintela okanye ukubuyisela umva ukungeva kakuhle?

Kuphononongo luka-2016, abaphandi basebenzise ukukhanya okukufutshane-kwe-infrared kwiiseli eziphicothayo kwi-vitro ngaphambi kokuzibeka phantsi koxinzelelo lwe-oxidative ngokuzityhila kwiityhefu ezahlukeneyo.Emva kokuveza iiseli ezibekwe ngaphambili kwityhefu ye-chemotherapy kunye ne-endotoxin, abaphandi bophononongo bafumanise ukuba ukukhanya kutshintshe imetabolism ye-mitochondrial kunye nempendulo yoxinzelelo lwe-oxidative ukuya kuthi ga kwiiyure ezingama-24 emva konyango.

"Sixela ukuhla kwee-cytokines ezivuthayo kunye namanqanaba oxinzelelo olubangelwa yi-NIR esetyenziswe kwiiseli ze-HEI-OC1 zokuphicotha ngaphambi kokuba unyango nge-gentamicin okanye i-lipopolysaccharide," babhala ababhali bokufunda.

Iziphumo zophononongo zibonise ukuba unyango lwangaphambili kunye nokukhanya okukufutshane kwe-infrared kunciphisa iimpawu zokukrala ezihambelana nokunyuka kweentlobo ze-oxygen esebenzayo kunye ne-nitric oxide.

Ukukhanya okukufutshane kwe-infrared okulawulwa phambi kokuba ityhefu yekhemikhali inokuthintela ukukhutshwa kwezinto ezikhokelela ekulahlekelweni kweendlebe.

Isifundo #1: Ngaba isibane esiBomvu singayibuyisela umva ilahleko yokuva?
Isiphumo sokukhanya kwe-infrared ekulahlekeni kokuva emva kwetyhefu ye-chemotherapy yavavanywa.Ukuva kuye kwavavanywa emva kokulawulwa kwe-gentamicin kwaye kwakhona emva kweentsuku ezili-10 zonyango olulula.

Ekuskeneni imifanekiso ye-electron microscopic, “LLLT inyuse kakhulu inani leeseli zeenwele phakathi kunye nokujika okusisiseko.Ukuva kwaphuculwa kakhulu nge-laser irradiation.Emva konyango lwe-LLLT, zombini umyinge wokuva kunye nokubalwa kweeseli zeenwele kuphuculwe kakhulu. ”

Ukukhanya okukufuphi kwe-infraRed okulawulwa emva kwetyhefu yekhemikhali kunokuphinda kukhule iiseli zeenwele ze-cochlear kunye nokubuyisela ukuva kwiimpuku.

Isifundo #2: Ngaba isibane esiBomvu singayibuyisela umva ilahleko yokuva?
Kolu phononongo, iigundane zavezwa kwingxolo ebukhali kwiindlebe zombini.Emva koko, iindlebe zabo zasekunene zakhanyiswa ngokukhanya okukufutshane kwe-infrared kunyango lwemizuzu engama-30 yonke imihla kangangeentsuku ezi-5.

Umlinganiselo wempendulo yengqondo yengqondo ibonakalise ukuchaneka okukhawulezileyo kokusebenza kokuva kumaqela aphathwa nge-LLLT xa kuthelekiswa neqela elingasebenzisi nyango kwiintsuku ze-2, 4, 7 kunye ne-14 emva kokuvezwa kwengxolo.Uphononongo lwe-morphological lubonakalise inqanaba eliphezulu kakhulu lokusinda kweenwele zeenwele kumaqela e-LLLT.

Ukukhangela izalathisi zoxinzelelo lwe-oxidative kunye ne-apoptosis kwiiseli ezingaphathwanga, abaphandi bafumene "i-immunoreactivities eyomeleleyo yabonwa kwizicubu zendlebe zangaphakathi zeqela elinganyangayo, ngelixa ezi zibonakaliso zehlisiwe kwiqela le-LLLT nge-165mW / cm (2) amandla. ukuxinana.”

"Iziphumo zethu zibonisa ukuba i-LLLT ineziphumo ze-cytoprotective ngokuchasene ne-NIHL ngokuthintelwa kwenkcazo ye-iNOS kunye ne-apoptosis."

Isifundo #3: Ngaba isibane esiBomvu singayibuyisela umva ilahleko yokuva?
Kuphononongo lwe-2012, iigundane ezisithoba zibonakaliswe kwingxolo ephezulu kunye nokusetyenziswa kokukhanya okukufutshane kwe-infrared ekubuyiseleni ukuva kwavavanywa.Ngomhla emva kokuvezwa kwengxolo enkulu, iindlebe ezisekhohlo zeegundane ziphathwe ngokukhanya okukufutshane kwe-infrared imizuzu engama-60 kwiintsuku ze-12 ngokulandelana.Iindlebe ezichanekileyo azizange ziphathwe kwaye ziqwalaselwe iqela lokulawula.

"Emva kokukhanya kwe-12, umda wokuva wawuphantsi kakhulu kwiindlebe zasekhohlo xa kuthelekiswa neendlebe zasekunene."Xa kujongwa kusetyenziswa i-electron microscope, inani leeseli zeenwele ezivalwayo kwiindlebe eziphathwayo lalilikhulu kakhulu kunelo leendlebe ezingaphendulwanga.

"Iziphumo zethu zibonisa ukuba umgangatho ophantsi we-laser irradiation ukhuthaza ukubuyiswa kwemida yokuva emva kwe-acute acoustic trauma."