I-Rosacea yimeko edla ngokubonakaliswa bubomvu bobuso kunye nokudumba.Ichaphazela malunga ne-5% yabemi behlabathi, kwaye nangona oonobangela baziwa, abaziwa kakhulu.Kuthathwa njengemeko yesikhumba sexesha elide, kwaye idla ngokuchaphazela abafazi baseYurophu / baseCaucasia ngaphezu kweminyaka eyi-30. Kukho iintlobo ezahlukeneyo ze-rosacea kwaye inokuchaphazela nabani na.
Unyango lokukhanya okubomvu lufundwe kakuhle kwizinto ezifana nokuphilisa ulusu, ukudumba ngokubanzi, i-collagen eluswini, kunye neemeko ezahlukeneyo zolusu ezinxulumene ne-acne.Ngokwendalo umdla ukhule ekusebenziseni isibane esibomvu kwirosacea.Kweli nqaku siza kujonga ukuba ngaba unyango olubomvu olubomvu (olwaziwa ngokuba yi-photobiomodulation, unyango lwe-LED, unyango lwe-laser, i-laser ebandayo, unyango olulula, i-LLLT, njl.) lunokunceda ukunyanga i-rosacea.
Iintlobo zeRosacea
Wonke umntu one-rosacea uneempawu ezahlukileyo kwaye ezizodwa.Ngelixa i-rosacea idla ngokunxulunyaniswa nokubomvu kobuso empumlweni nasezihlathini, kukho ezinye iimpawu ezinokuthi zicazululwe kwaye zihlelwe zibe yi-rosacea 'subtypes':
I-Subtype 1, ekubhekiselwa kuyo njenge-'Erythematotelangiectatic Rosacea' (ETR), yi-rosacea ebambekayo ebonisa ububomvu bobuso, ukudumba kolusu, imithambo yegazi ekufutshane nomphezulu kunye namaxesha okugungxulwa.I-Erythema ivela kwigama lesiGrike elithi erythros, elithetha ubomvu - kwaye libhekisela kwisikhumba esibomvu.
I-Subtype 2, i-Acne rosacea (igama lesayensi - i-papulopustular), yi-rosacea apho ulusu olubomvu ludibaniswa nokuqhambuka okuqhubekayo okanye okungapheliyo okufana ne-acne (i-pustules kunye ne-papules, kungekhona i-blackheads).Olu hlobo lunokubangela ukuvutha okanye ukuvutha.
I-Subtype 3, i-AKA phymatous rosacea okanye i-rhinophyma, luhlobo olunqabileyo lwe-rosacea kwaye ibandakanya iindawo zobuso eziya ziba ngqindilili ngokuba nkulu - ngokuqhelekileyo impumlo (impumlo yetapile).Ixhaphake kakhulu kumadoda amadala kwaye iqala njengenye i-rosacea.
I-Subtype 4 yi-rosacea yeso, okanye i-rosacea ye-ocular, kwaye ibandakanya amehlo egazi, amehlo anamanzi, ukuvakalelwa kwento esweni, ukutshisa, ukurhawuzelela kunye nokuqwenga.
Ukwazi malunga ne-subtypes ye-rosacea kubalulekile ekuqinisekiseni ukuba unayo ngokwenene.Ukuba akukho nto yenziwayo ukulungisa i-rosacea, ithande ukuba mbi ngakumbi ngokuhamba kwexesha.Ngethamsanqa, ukusetyenziswa konyango lokukhanya okubomvu ekuphatheni i-rosacea akutshintshi kunye ne-subtype.Oku kuthetha ukuba iprotocol efanayo yonyango lokukhanya okubomvu iya kusebenza kuzo zonke iintlobo ezincinci.Ngoba?Makhe sijonge oonobangela be-rosacea.
Oyena nobangela weRosacea
(...kwaye kutheni unyango olulula lunokunceda)
Kwiminyaka emininzi eyadlulayo, i-rosacea ekuqaleni yayikholelwa ukuba sisiphumo sosulelo lwebhaktiriya.Njengoko amayeza okubulala iintsholongwane (kuquka i-tetracycline) aye asebenza kwinqanaba elithile ukulawula iimpawu, kwabonakala ngathi yithiyori elungileyo….kodwa ngokukhawuleza kwafunyaniswa ukuba akukho bhaktheriya ebandakanyekayo.
Uninzi lwamagqirha kunye neengcali kwi-rosacea kule mihla baya kukuxelela ukuba i-rosacea inzima kwaye akukho mntu ufumene unobangela.Abanye baya kukhomba kwi-Demodex mites njengesizathu, kodwa phantse wonke umntu unazo kwaye ayinguye wonke umntu onayo i-rosacea.
Emva koko baya kuthi endaweni yoko badwelise 'iziphembeleli' ezahlukeneyo endaweni yesizathu, okanye benze iingcebiso ezingachazwanga ukuba imfuzo kunye nemiba yokusingqongileyo ingunobangela.Nangona izinto zofuzo okanye ze-epigenetic zinokubangela ukuba umntu afumane i-rosacea (enxulumene nomnye umntu), abayiqinisi - ayiyena unobangela.
Izinto ezahlukeneyo ngokuqinisekileyo zinegalelo kubukhali beempawu zerosacea (icaffeine, iziqholo, ukutya okuthile, imozulu ebandayo/eshushu, uxinzelelo, utywala, njl.njl.), kodwa nazo azingonobangela.
Ke yintoni?
Imikhondo kunobangela
Isikhokelo sokuqala kwisizathu kukuba i-rosacea idla ngokukhula emva kweminyaka engama-30. Eli lixesha apho iimpawu zokuqala zokuguga zibonakala.Uninzi lwabantu luya kuqaphela iinwele zabo zokuqala ezingwevu kunye nesikhumba esincinci sokuqala sishwabene kule minyaka.
Omnye umkhondo yinto yokuba amayeza okubulala iintsholongwane anceda ukulawula iimpawu-nangona akukho usulelo lokwenyani (ingcebiso: amayeza okubulala iintsholongwane anokuba neziphumo zexesha elifutshane zokuchasa ukudumba).
Ukuhamba kwegazi esikhumbeni esichaphazelekayo yi-rosacea yi-3 ukuya kwamaxesha ama-4 aphezulu kunesikhumba esiqhelekileyo.Esi siphumo se-hyperemia senzeka xa izicubu kunye neeseli zingakwazi ukukhupha i-oksijini egazini.
Siyazi ukuba i-rosacea ayingomcimbi nje wokuthambisa, kodwa ibandakanya utshintsho olubalulekileyo lokukhula kwefibrotic eluswini (kungoko impumlo yeitapile kuhlobo olusezantsi lwesi-3) kunye nokukhula komthambo wegazi ohlaselayo (kungoko imithambo/ukugungxula).Xa ezi mpawu zifana ngqo zisenzeka kwenye indawo emzimbeni (umz. i-uterine fibroids) zifuna ukuba kwenziwe uphando olubalulekileyo, kodwa eluswini zithathwa njengezinto zokuthambisa ezimele 'zilawulwe' 'ngokuphepha izinto ezibangela ukuba zibangele', kwaye kamva kwanotyando lokususa ulusu olujiyileyo. .
I-Rosacea ngumba obalulekileyo kuba oyena nobangela ziinkqubo zomzimba ezinzulu emzimbeni.Imeko yefiziyoloji ekhokelela kolu tshintsho lolusu aluchaphazeli ulusu kuphela – luchaphazela nawo wonke umzimba wangaphakathi.
Ukugungxulwa, ukukhula / imithambo yegazi ehlaselayo kunye nokuqina kolusu kunokubonwa ngokukhawuleza kwi-rosacea, kuba ibonakala eluswini - umphezulu womzimba.Ngandlela-thile, kuyintsikelelo ukufumana iimpawu ze-rosacea, kuba ibonisa ukuba kukho into engalunganga ngaphakathi.Ukulahleka kweenwele zendoda yinto efanayo kuba ikhomba kwi-dysregulation ye-hormonal.
Iziphene zeMitochondrial
Yonke imigqaliselo kunye nemilinganiselo malunga ne-rosacea ikhomba iingxaki ze-mitochondrial njengengcambu ye-rosacea.
IMitochondria ayikwazi ukusebenzisa ioksijini ngokufanelekileyo xa yonakele.Ukungakwazi ukusebenzisa ioksijini kwandisa ukuhamba kwegazi kwithishu.
I-Mitochondria ivelisa i-lactic acid xa ingakwazi ukufumana nokusebenzisa i-oksijini, nto leyo ekhokelela kwi-vasodilation ngokukhawuleza kunye nokukhula kwe-fibroblasts.Ukuba le ngxaki ithatha ixesha elide, imithambo yegazi emitsha iqala ukukhula.
Izinto ezahlukeneyo zehomoni kunye nezokusingqongileyo zinokufaka isandla ekusebenzeni kakubi kwe-mitochondrial, kodwa kwimeko yonyango olubomvu, eyona mpembelelo ibalulekileyo isuka kwimolekyuli ebizwa ngokuba yiNitric Oxide.
Unyango oluBomvu oluKhanya kunye neRosacea
Ithiyori ephambili echaza iziphumo zonyango olukhanyayo lusekwe kwimolekyuli ebizwa ngokuba yiNitric Oxide (NO).
Le molekyuli enokuba nemiphumo eyahlukeneyo emzimbeni, njengokuthintela ukuveliswa kwamandla, i-vasodilation / ukwandisa imithwalo yegazi, njalo njalo.Eyona nto sinomdla kuyo kakhulu kunyango olulula kukuba le HAYI ibophelela kwindawo ephambili kwikhonkco lothutho lwe-electron ye-mitochondrial, ukumisa ukuhamba kwamandla.
Ithintela amanqanaba okugqibela empendulo yokuphefumla, ngoko ke ikuyekise ukufumana eyona chunk yamandla (ATP) kunye nayo nayiphi na icarbon dioxide esuka kwiglucose/oksijini.Ke xa abantu benemilinganiselo ephantsi yemetabolism ngokusisigxina njengoko beguga okanye befumana amaxesha oxinzelelo / yindlala, le HAYI ihlala inoxanduva.Iyavakala xa ucinga ngayo, kwindalo okanye ekusindeni, udinga indlela yokwehlisa isantya semetabolism ngamaxesha okufumaneka okusezantsi kokutya / ikhalori.Ayinangqiqo kwihlabathi lanamhlanje apho AKUKHO amanqanaba angaphenjelelwa ziintlobo ezithile ze-amino acids ekutyeni, ukungcoliseka komoya, ukungunda, ezinye izinto zokutya, ukukhanya okwenziwayo, njl njl. Ukungabikho kwekharbon diokside emzimbeni wethu nako. inyusa ukudumba.
Ukunyanga ukukhanya kwandisa ukuveliswa kwamandla omabini (ATP) kunye ne-carbon dioxide (CO2).I-CO2 yona inqanda iintlobo ezahlukeneyo ze-cytokines ze-pro-inflammatory kunye ne-prostaglandins.Ngoko unyango olulula lunciphisa inani lokuvuvukala emzimbeni / kwindawo.
Kwi-rosacea eyona nto iphambili kukuba unyango olulula luza kunciphisa ukudumba kunye nobubomvu kwindawo, kwaye luphinde lusombulule ingxaki yokusetyenziswa kweoksijini ephantsi (ebangele ukukhula komthambo wegazi kunye nokukhula kwe-fibroblast).
Isishwankathelo
Kukho iintlobo ezincinci kunye nokubonakaliswa kwe-rosacea
I-Rosacea luphawu lokuguga, njengemibimbi kunye neenwele ezingwevu
Unobangela we-rosacea unciphisa umsebenzi we-mitochondrial kwiiseli
Unyango olubomvu olukhanyayo lubuyisela i-mitochondria kwaye lunciphisa ukuvuvukala, ukukhusela i-rosacea
Ixesha lokuposa: Sep-30-2022